The FIRST-ABC trial shows that That HFNC did not meet noninferiority criteria when compared to CPAP in children requiring respiratory support after extubation and may potentially lead to higher 180-day mortality. The trial supports that clinicians may favor the use of CPAP until more evidence becomes available. I suggest to read this editorial in JAMA as it shed more light on the preferred approaches in the management of respiratory failure in PICU.
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