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General Critical Care

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In a multi-center, double-blind randomized trial across eight Dutch ICUs, 132 critically ill adults with delirium were administered intravenous haloperidol or placebo, resulting in no significant difference in delirium- and coma-free days. The study, which was terminated early for futility, also found haloperidol might decrease the need for benzodiazepines and reduce agitation-related behaviors, although these secondary outcomes were not statistically conclusive.

Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial | Critical Care | Full Text (

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