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Sepsis & Septic Shock

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Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock


The study aimed to compare the effectiveness of adding fludrocortisone to hydrocortisone vs hydrocortisone alone among patients with septic shock. The study was a retrospective cohort study using the enhanced claims-based Premier Healthcare Database from 2016 to 2020. The primary outcome was a composite of hospital death or discharge to hospice. The results showed that the addition of fludrocortisone on the same calendar day that hydrocortisone treatment was initiated was superior to hydrocortisone alone among adult patients with septic shock who began hydrocortisone treatment. The study concluded that the addition of fludrocortisone to hydrocortisone may be a more effective treatment option for septic shock patients.


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Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock | Critical Care Medicine | JAMA Internal Medicine | JAMA Network


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