A two-day course of antibiotics for complicated appendicitis Appendicitis
This open-label, non-inferiority trial conducted across 15 Dutch hospitals assessed the efficacy and safety of reducing postoperative intravenous antibiotic duration from 5 days to 2 days in patients aged ≥8 years with complex appendicitis, amidst rising concerns regarding antimicrobial resistance. The primary endpoint was a composite of infectious complications and mortality within a 90-day post-appendicectomy period. The trial showed no significant difference in the primary endpoint between the two groups, suggesting that a shorter antibiotic course is non-inferior to a longer one, with additional benefits of lowered adverse effects, and potentially reduced hospital stay and costs.
Based on this study, would you treat complex appendicitis after appendicectomy with 2 day-course of antibiotics?
0%Yes
0%No
0%It depends (please explain the comment section)
It depends on cases, some came late and with complications