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Sepsis & Septic Shock

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A two-day course of antibiotics for complicated appendicitis Appendicitis


This open-label, non-inferiority trial conducted across 15 Dutch hospitals assessed the efficacy and safety of reducing postoperative intravenous antibiotic duration from 5 days to 2 days in patients aged ≥8 years with complex appendicitis, amidst rising concerns regarding antimicrobial resistance. The primary endpoint was a composite of infectious complications and mortality within a 90-day post-appendicectomy period. The trial showed no significant difference in the primary endpoint between the two groups, suggesting that a shorter antibiotic course is non-inferior to a longer one, with additional benefits of lowered adverse effects, and potentially reduced hospital stay and costs.


Based on this study, would you treat complex appendicitis after appendicectomy with 2 day-course of antibiotics?

  • 0%Yes

  • 0%No

  • 0%It depends (please explain the comment section)


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