Lower vs Higher Fluid Volumes in Adult Patients With Sepsis
In a systematic review updating the optimal IV fluid volume strategy for adult sepsis patients, the study compared lower vs. higher fluid volumes. The results, based on trials with low risk of bias, indicated that lower IV fluid volumes have minimal to no impact on all-cause mortality (Relative Risk: 0.99, 97% CI, 0.89-1.10) or serious adverse events (Relative Risk: 0.95, 97% CI, 0.83-1.07) compared to higher volumes. However, these conclusions come with some imprecision, not ruling out potential benefits or risks. Notably, the trials did not report on health-related quality of life.