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Sepsis & Septic Shock

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The 30 mL/kg fluid resuscitation to all patients as per surviving sepsis campaign guidelines has been challenged in a nice article by Paul Marik that you may be interested to look at here:


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024756/#:~:text=Furthermore%2C%20there%20is%20no%20evidence,greatest%20hoaxes%20of%20modern%20medicine.


The conclusion suggested that an individualized, hemodynamically guided and fluid restricted approach to fluid therapy will improve the outcomes of patients with severe sepsis and septic shock.


I think the CLASSIC trial (Restrictive Fluid in Septic Shock) results will be released in June and will shed more light on the topic before any change in the guidelines.

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Hadi Al Yousuf
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