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Sepsis & Septic Shock

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The Clinical Significance of Anaerobic Coverage in the Antibiotic Treatment of Aspiration Pneumonia: A Systematic Review and Meta-Analysis

This article is a systematic review and meta-analysis of studies that compared antibiotics with and without anaerobic coverage in the treatment of aspiration pneumonia. The authors found that anaerobic coverage did not improve mortality, resolution of pneumonia, length of hospital stay, recurrence of pneumonia, or adverse effects. They concluded that anaerobic coverage is not recommended in the treatment of aspiration pneumonia based on current data.


(A) Mortality; (B) Clinical cure rate. Forest plots comparing outcomes in groups given antibiotic treatment with or without anaerobic coverage. The blue square represents the odds ratios of individual studies. The black diamond represents the pooled result.

Yoshimatsu, Y.; Aga, M.; Komiya, K.; Haranaga, S.; Numata, Y.; Miki, M.; Higa, F.; Senda, K.; Teramoto, S. The Clinical Significance of Anaerobic Coverage in the Antibiotic Treatment of Aspiration Pneumonia: A Systematic Review and Meta-Analysis. J. Clin. Med.2023, 12, 1992. https://doi.org/10.3390/jcm12051992

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