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Sepsis & Septic Shock

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Impact of Left Ventricular Systolic Function on Mortality in Sepsis and Septic Shock: A Retrospective Cohort Study

In this retrospective cohort study, the researchers aimed to investigate the association between left ventricular (LV) systolic function and in-hospital mortality in patients with sepsis and septic shock. They included all adult patients admitted to the medical ICU with sepsis or septic shock who underwent transthoracic echocardiography within 3 days of admission. The patients were divided into five groups based on LV ejection fraction (LVEF). The results revealed a U-shaped association between LVEF and in-hospital mortality, with both severely reduced LV systolic dysfunction (LVEF < 25%) and hyperdynamic LV (LVEF ≥ 70%) being independently associated with significantly higher mortality compared to the reference group (LVEF 55% to 70%). The study highlights the complexity of LV systolic function's impact on mortality in sepsis and septic shock, indicating the need for personalized resuscitation and vasopressor strategies in these patients.

Is Left Ventricular Systolic Dysfunction Associated With Increased Mortality Among Patients With Sepsis and Septic Shock? - CHEST (

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