COVI-PRONE Trial

Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory Failure.

SETPOINT2 Trial

Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation.

FIRST-ABC Trial

Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Following Extubation on Liberation from Respiratory Support in Critically Ill Children.

Esmolol in Septic Shock Patients

Esmolol to Treat the Hemodynamic Effects of Septic Shock: A Randomized Controlled Trial.

RePHILL Trial

Resuscitation with blood products in patients with trauma-related hemorrhagic shock receiving prehospital care.

PLUS Trial

Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults.

TELSTAR Trial

Treating Rhythmic and Periodic EEG Patterns in Comatose Survivors of Cardiac Arrest.

CHOICE Trial

Effect of Intra-arterial Alteplase vs Placebo Following Successful Thrombectomy on Functional Outcomes in Patients with Large Vessel Occlusion Acute Ischemic Stroke.

Bougie Trial

Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation.

COCA Trial

Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest.

VAM-IHCA Trial

Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients with In-Hospital Cardiac Arrest.

REST Trial

Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure.