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General Critical Care

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Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia: A Target Trial Emulation Using MINT Trial Data: Annals of Internal Medicine: Vol 0, No 0


This secondary analysis of the MINT trial evaluated four transfusion thresholds (<10 g/dL, <9 g/dL, <8 g/dL, and <7 g/dL) in 3492 patients with acute MI and anemia. The 30-day risk for death or recurrent MI increased progressively as transfusion thresholds decreased, with a 14.8% risk at <10 g/dL, 15.1% at <9 g/dL, 15.9% at <8 g/dL, and 18.3% at <7 g/dL. However, wide confidence intervals preclude definitive conclusions. These findings suggest higher thresholds may reduce risk, but further research is needed due to imprecision in the estimates


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