SONIA TRIAL: Steroids for CAP in Africa
In a randomized trial across 18 public hospitals in Kenya involving 2,180 adults with community-acquired pneumonia (CAP), patients received either standard care or standard care plus oral low-dose glucocorticoids for 10 days. By day 30, mortality was 22.6% in the glucocorticoid group and 26.0% in the standard-care group (hazard ratio 0.84; 95% CI, 0.73–0.97; P=0.02). Adverse events were similar between groups. Conclusion: Adjunctive low-dose glucocorticoids reduced mortality without increasing adverse events, even in low-resource settings.
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