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Effects of Hypothermia vs Normothermia on Societal Participation and Cognitive Function at 6 Months in Survivors After Out-of-Hospital Cardiac Arrest

The "TTM2" trial compared the effects of cooling (hypothermia) and maintaining normal temperature (normothermia) in people who survived out-of-hospital cardiac arrest (OHCA). The study aimed to see if these approaches had different impacts on functional outcomes and cognitive function after six months.



The trial involved 1861 comatose adult OHCA patients, split into hypothermia and normothermia groups. After six months, 836 survivors participated in the follow-up.

Results showed no significant difference between the two groups in terms of societal participation or cognitive function. Many survivors faced limitations in daily activities, and cognitive issues were common regardless of treatment.


In conclusion, hypothermia did not show better outcomes than normothermia in terms of functional or cognitive recovery after six months in OHCA survivors.


Effects of Hypothermia vs Normothermia on Societal Participation and Cognitive Function at 6 Months in Survivors After Out-of-Hospital Cardiac Arrest: A Predefined Analysis of the TTM2 Randomized Clinical Trial | Cardiology | JAMA Neurology | JAMA Network


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