Epinephrine in Out-of-Hospital Cardiac Arrest
A Network Meta-analysis and Subgroup Analyses of Shockable and Nonshockable Rhythms
Standard-dose epinephrine, high-dose epinephrine, and the combination of epinephrine with vasopressin are associated with increased ROSC and survival to hospital admission post-OHCA compared to placebo or no treatment. However, these agents don't necessarily enhance survival to discharge or ensure a good functional outcome. Notably, standard-dose epinephrine does improve survival to discharge for patients with a nonshockable rhythm but not for those with a shockable rhythm.