Sepsis & Septic Shock

Use and Outcomes of Peripheral Vasopressors in Early Sepsis-Induced Hypotension Across Michigan Hospitals - CHEST (chestnet.org)

Do We Need to Administer Fludrocortisone in Addition to Hydr... : Critical Care Medicine (lww.com)

This systematic review and Bayesian network meta-analysis, involving 19 studies and 95,841 patients, assessed hydrocortisone with/without fludrocortisone versus placebo in septic shock. Hydrocortisone plus fludrocortisone was associated with reduced short-term mortality (OR: 0.79; 95% CrI: 0.64-0.99; NNT: 21) compared to placebo, showing potential benefits with minimal adverse events. However, findings suggest cautious interpretation due to low certainty evidence and a broad NNT range, indicating the need for further large-scale RCTs.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2815769

https://www.nejm.org/doi/10.1056/NEJMoa2304748 In a trial, 661 patients with complicated UTI were randomized to receive cefepime–taniborbactam or meropenem. Of 436 in the microITT population, 70.6% on cefepime–taniborbactam vs. 58.0% on meropenem achieved composite success, showing superior efficacy (P=0.009). Safety profiles were similar.