Respiratory Failure & Mechanical Ventilation

Practical Applications in Clinical Practice

Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults | New England Journal of Medicine

1. No Mortality Benefit

• The trial found no statistically significant difference in 28-day in-hospital mortality between ketamine (28.1%) and etomidate (29.1%) groups (adjusted risk difference −0.8%, 95% CI −4.5 to 2.9; P = 0.65).

• Implication: Either agent may be appropriate from a mortality standpoint, allowing clinicians to prioritize other patient-specific factors.

2. Risk Stratification

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Effects of 30% vs. 60% inspired oxygen fraction during mechanical ventilation on postoperative atelectasis: a randomised controlled trial

A study analyzed the impact of different oxygen levels (30% vs. 60%) during mechanical ventilation on postoperative atelectasis. The research included 120 patients, split evenly between the two oxygen groups. Results showed no significant difference in atelectasis volume between the groups. Other factors like aeration regions and oxygenation also remained comparable.

Conclusions: Using 30% oxygen during ventilation doesn't reduce postoperative atelectasis compared to 60%.

Effects of 30% vs. 60% inspired oxygen fraction during mechanical ventilation on postoperative atelectasis: a randomised controlled trial | BMC Anesthesiology | Full Text (biomedcentral.com)