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Respiratory Failure & Mechanical Ventilation

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The respiratory drive is the intensity of the neural stimulus that determines how much the respiratory muscles contract. Excessive or low respiratory drive can be encountered in different clinical scenarios in patients on mechanical ventilation. High respiratory drive potentially leads to an injurious effect on the diaphragm (myotrauma), and on the lung (patient-self-inflicted lung injury). The low respiratory drive may cause disuse atrophy which leads to difficulty in weaning off the ventilator. Occlusion pressure at 100 ms (P 0.1) is the negative pressure measured 100 ms after the initiation of an inspiratory effort performed against a closed respiratory circuit and has been used as an indirect measure of the respiratory drive.



Please observe the P0.1 procedure and value in the. Above graph and provide your answer to this question:


What does a value of P0.1 of -3.5 indicate?

  • 0%High respiratory drive

  • 0%Normal respiratory drive

  • 0%Low respiratory drive

  • 0%Weak respiratory muscles


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